I don't see the 80mm fans or the possible limitation of USB2 on the front ports as huge issues.

It's very likely that the front USB ports will work just fine. I'm not sure what if any physical or electrical difference there might be for USB2 vs. USB3 on front panel connections other than maybe the number of twists per inch in the wires.

As for the fans, unless you are planning on having a high wattage CPU or more than one HDD I don't see there being a problem keeping the case cool. Most of the high power video cards already exhaust out the back of the case.